Title |
Ovarian Cancer: The Fallopian Tube as the Site of Origin and Opportunities for Prevention
|
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Published in |
Frontiers in oncology, May 2016
|
DOI | 10.3389/fonc.2016.00108 |
Pubmed ID | |
Authors |
Sophia H. L. George, Ruslan Garcia, Brian M. Slomovitz |
Abstract |
High-grade serous carcinoma (HGSC) is the most common and aggressive histotype of epithelial ovarian cancer (EOC), and it is the predominant histotype associated with hereditary breast and ovarian cancer syndrome (HBOC). Mutations in BRCA1 and BRCA2 are responsible for most of the known causes of HBOC, while mutations in mismatch repair genes and several genes of moderate penetrance are responsible for the remaining known hereditary risk. Women with a history of familial ovarian cancer or with known germline mutations in highly penetrant genes are offered the option of risk-reducing surgery that involves the removal of the ovaries and fallopian tubes (salpingo-oophorectomy). Growing evidence now supports the fallopian tube epithelia as an etiological site for the development of HGSC and consequently, salpingectomy alone is emerging as a prophylactic option. This review discusses the site of origin of EOC, the rationale for risk-reducing salpingectomy in the high-risk population, and opportunities for salpingectomy in the low-risk population. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 17% |
United States | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | <1% |
India | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 126 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 21 | 16% |
Student > Bachelor | 21 | 16% |
Student > Ph. D. Student | 20 | 16% |
Researcher | 11 | 9% |
Student > Postgraduate | 8 | 6% |
Other | 17 | 13% |
Unknown | 31 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 42 | 33% |
Biochemistry, Genetics and Molecular Biology | 23 | 18% |
Agricultural and Biological Sciences | 10 | 8% |
Nursing and Health Professions | 5 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 7 | 5% |
Unknown | 39 | 30% |