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Association of Family History of Type 2 Diabetes with Prostate Cancer: A National Cohort Study

Overview of attention for article published in Frontiers in oncology, August 2016
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Title
Association of Family History of Type 2 Diabetes with Prostate Cancer: A National Cohort Study
Published in
Frontiers in oncology, August 2016
DOI 10.3389/fonc.2016.00194
Pubmed ID
Authors

Jianguang Ji, Jan Sundquist, Kristina Sundquist

Abstract

Personal history of type 2 diabetes mellitus (T2DM) is associated with a lower incidence of prostate cancer, but the underlying mechanisms are largely unknown. We hypothesized that genetic factors that are involved in the development of T2DM might protect against prostate cancer. We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, to examine the risk of prostate cancer among men with a family history of T2DM. Standardized incidence ratios were used to calculate the relative risk. The overall risk of prostate cancer among men with a familial history of T2DM was 0.87 (95% CI: 0.86-0.89) as compared to matched controls. The risk was even lower for those multiple affected relatives with T2DM, and it was 0.86 for those with two affected relatives and 0.67 for those with three and more affected relatives. Family history of T2DM was associated with a lower incidence of prostate cancer, and the risk was even lower for those with more than one affected relative. Our study strongly suggests that genetic factors or shared familial factors, such as obesity, that contributed to T2DM may protect against prostate cancer.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 21%
Student > Bachelor 3 16%
Student > Master 3 16%
Researcher 2 11%
Librarian 1 5%
Other 2 11%
Unknown 4 21%
Readers by discipline Count As %
Medicine and Dentistry 5 26%
Nursing and Health Professions 4 21%
Agricultural and Biological Sciences 2 11%
Biochemistry, Genetics and Molecular Biology 1 5%
Decision Sciences 1 5%
Other 1 5%
Unknown 5 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2016.
All research outputs
#22,759,452
of 25,373,627 outputs
Outputs from Frontiers in oncology
#15,918
of 22,416 outputs
Outputs of similar age
#309,102
of 349,074 outputs
Outputs of similar age from Frontiers in oncology
#41
of 44 outputs
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So far Altmetric has tracked 22,416 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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