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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Targeting SOX2 as a Therapeutic Strategy in Glioblastoma
|
|---|---|
| Published in |
Frontiers in oncology, October 2016
|
| DOI | 10.3389/fonc.2016.00222 |
| Pubmed ID | |
| Authors |
Laura Garros-Regulez, Idoia Garcia, Estefania Carrasco-Garcia, Aquilino Lantero, Paula Aldaz, Leire Moreno-Cugnon, Olatz Arrizabalaga, Jose Undabeitia, Sergio Torres-Bayona, Jorge Villanua, Irune Ruiz, Larraitz Egaña, Nicolas Sampron, Ander Matheu |
| Abstract |
Glioblastoma is the most common and malignant brain cancer in adults. Current therapy consisting of surgery followed by radiation and temozolomide has a moderate success rate and the tumor reappears. Among the features that a cancer cell must have to survive the therapeutic treatment and reconstitute the tumor is the ability of self-renewal. Therefore, it is vital to identify the molecular mechanisms that regulate this activity. Sex-determining region Y (SRY)-box 2 (SOX2) is a transcription factor whose activity has been associated with the maintenance of the undifferentiated state of cancer stem cells in several tissues, including the brain. Several groups have detected increased SOX2 levels in biopsies of glioblastoma patients, with the highest levels associated with poor outcome. Therefore, SOX2 silencing might be a novel therapeutic approach to combat cancer and particularly brain tumors. In this review, we will summarize the current knowledge about SOX2 in glioblastoma and recapitulate several strategies that have recently been described targeting SOX2 in this malignancy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 185 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Unknown | 184 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 21% |
| Student > Bachelor | 26 | 14% |
| Researcher | 23 | 12% |
| Student > Master | 20 | 11% |
| Student > Doctoral Student | 14 | 8% |
| Other | 20 | 11% |
| Unknown | 43 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 60 | 32% |
| Medicine and Dentistry | 24 | 13% |
| Agricultural and Biological Sciences | 20 | 11% |
| Neuroscience | 13 | 7% |
| Immunology and Microbiology | 4 | 2% |
| Other | 12 | 6% |
| Unknown | 52 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2022.
All research outputs
#8,270,860
of 25,394,764 outputs
Outputs from Frontiers in oncology
#3,082
of 22,440 outputs
Outputs of similar age
#115,548
of 321,058 outputs
Outputs of similar age from Frontiers in oncology
#10
of 58 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 22,440 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,058 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.