Title |
The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics
|
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Published in |
Frontiers in oncology, April 2017
|
DOI | 10.3389/fonc.2017.00055 |
Pubmed ID | |
Authors |
Amado Carreras-Sureda, Philippe Pihán, Claudio Hetz |
Abstract |
Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This functional integration is exerted through discrete interorganelle structures known as mitochondria-associated membranes (MAMs). At these domains, ER/mitochondria physically associate to dynamically adjust metabolic demands and the response to stress stimuli. Here, we provide a focused overview of how the ER shapes the function of the mitochondria, giving a special emphasis to the significance of local signaling of the unfolded protein response at MAMs. The implications to cell fate control and the progression of cancer are also discussed. |
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Germany | 1 | 9% |
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Switzerland | 1 | 9% |
Unknown | 6 | 55% |
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Scientists | 2 | 18% |
Mendeley readers
Geographical breakdown
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Finland | 1 | 1% |
Unknown | 76 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 18% |
Student > Ph. D. Student | 13 | 17% |
Student > Master | 11 | 14% |
Student > Bachelor | 7 | 9% |
Student > Doctoral Student | 6 | 8% |
Other | 12 | 16% |
Unknown | 14 | 18% |
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Neuroscience | 7 | 9% |
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Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 6 | 8% |
Unknown | 15 | 19% |