Title |
Targeting Lung Cancer Stem Cells: Research and Clinical Impacts
|
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Published in |
Frontiers in oncology, May 2017
|
DOI | 10.3389/fonc.2017.00080 |
Pubmed ID | |
Authors |
Norashikin Zakaria, Nazilah Abdul Satar, Noor Hanis Abu Halim, Siti Hawa Ngalim, Narazah Mohd Yusoff, Juntang Lin, Badrul Hisham Yahaya |
Abstract |
Lung cancer is the most common cancer worldwide, accounting for 1.8 million new cases and 1.6 million deaths in 2012. Non-small cell lung cancer (NSCLC), which is one of two types of lung cancer, accounts for 85-90% of all lung cancers. Despite advances in therapy, lung cancer still remains a leading cause of death. Cancer relapse and dissemination after treatment indicates the existence of a niche of cancer cells that are not fully eradicated by current therapies. These chemoresistant populations of cancer cells are called cancer stem cells (CSCs) because they possess the self-renewal and differentiation capabilities similar to those of normal stem cells. Targeting the niche of CSCs in combination with chemotherapy might provide a promising strategy to eradicate these cells. Thus, understanding the characteristics of CSCs has become a focus of studies of NSCLC therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 105 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 16% |
Student > Master | 17 | 16% |
Researcher | 10 | 10% |
Student > Bachelor | 10 | 10% |
Student > Doctoral Student | 9 | 9% |
Other | 14 | 13% |
Unknown | 28 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 29 | 28% |
Agricultural and Biological Sciences | 13 | 12% |
Medicine and Dentistry | 12 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Chemistry | 5 | 5% |
Other | 12 | 11% |
Unknown | 29 | 28% |