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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells
|
|---|---|
| Published in |
Frontiers in oncology, July 2017
|
| DOI | 10.3389/fonc.2017.00143 |
| Pubmed ID | |
| Authors |
Alessandra Audia, Siobhan Conroy, Rainer Glass, Krishna P. L. Bhat |
| Abstract |
Glioblastoma is the most common and highly malignant primary brain tumor, and patients affected with this disease exhibit a uniformly dismal prognosis. Glioma stem-like cells (GSCs) are a subset of cells within the bulk tumor that possess self-renewal and multi-lineage differentiation properties similar to somatic stem cells. These cells also are at the apex of the cellular hierarchy and cause tumor initiation and expansion after chemo-radiation. These traits make them an attractive target for therapeutic development. Because GSCs are dependent on the brain microenvironment for their growth, and because non-tumorigenic cell types in the microenvironment can influence GSC phenotypes and treatment response, a better understanding of these cell types is needed. In this review, we provide a focused overview of the contributions from the microenvironment to GSC homing, maintenance, phenotypic plasticity, and tumor initiation. The interaction of GSCs with the vascular compartment, mesenchymal stem cells, immune system, and normal brain cell types are discussed. Studies that provide mechanistic insight into each of these GSC-microenvironment interactions are warranted in the future. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 104 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 15% |
| Student > Bachelor | 13 | 13% |
| Student > Doctoral Student | 11 | 11% |
| Student > Master | 9 | 9% |
| Researcher | 8 | 8% |
| Other | 16 | 15% |
| Unknown | 31 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 19% |
| Medicine and Dentistry | 17 | 16% |
| Agricultural and Biological Sciences | 13 | 13% |
| Neuroscience | 12 | 12% |
| Immunology and Microbiology | 4 | 4% |
| Other | 9 | 9% |
| Unknown | 29 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2017.
All research outputs
#23,269,088
of 25,932,719 outputs
Outputs from Frontiers in oncology
#16,293
of 22,839 outputs
Outputs of similar age
#289,528
of 329,717 outputs
Outputs of similar age from Frontiers in oncology
#66
of 77 outputs
Altmetric has tracked 25,932,719 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,839 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,717 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.