Title |
The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities
|
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Published in |
Frontiers in oncology, November 2017
|
DOI | 10.3389/fonc.2017.00262 |
Pubmed ID | |
Authors |
Kate L. Hertweck, Santanu Dasgupta |
Abstract |
Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both execute similar processes but with different cellular and molecular effects. Given the number of reviews currently available which describe the functional implications of mitochondrial mutations in cancer, this article focuses on documenting current knowledge in the abundance and distribution of somatic mitochondrial mutations, followed by elucidation of processes which affect the fate of mutations in cancer cells. The conclusion includes an overview of translational implications for mtDNA mutations, as well as recommendations for future research uniting mitochondrial variants and tumorigenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 4 | 13% |
United States | 1 | 3% |
Mexico | 1 | 3% |
Venezuela, Bolivarian Republic of | 1 | 3% |
Unknown | 23 | 77% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 23 | 77% |
Scientists | 6 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 123 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 24% |
Researcher | 24 | 20% |
Student > Master | 9 | 7% |
Student > Bachelor | 8 | 7% |
Student > Doctoral Student | 6 | 5% |
Other | 15 | 12% |
Unknown | 31 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 43 | 35% |
Agricultural and Biological Sciences | 17 | 14% |
Medicine and Dentistry | 12 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Computer Science | 2 | 2% |
Other | 13 | 11% |
Unknown | 33 | 27% |