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Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia

Overview of attention for article published in Frontiers in oncology, November 2017
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Mentioned by

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3 X users

Citations

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38 Dimensions

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145 Mendeley
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Title
Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia
Published in
Frontiers in oncology, November 2017
DOI 10.3389/fonc.2017.00263
Pubmed ID
Authors

M. Ryan Corces, Howard Y. Chang, Ravindra Majeti

Abstract

Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow characterized by an uncontrolled proliferation of undifferentiated myeloid lineage cells. Decades of research have demonstrated that AML evolves from the sequential acquisition of genetic alterations within a single lineage of hematopoietic cells. More recently, the advent of high-throughput sequencing has enabled the identification of a premalignant phase of AML termed preleukemia. Multiple studies have demonstrated that AML can arise from the accumulation of mutations within hematopoietic stem cells (HSCs). These HSCs have been termed "preleukemic HSCs" as they represent the evolutionary ancestors of the leukemia. Through examination of the biological and clinical characteristics of these preleukemic HSCs, this review aims to shed light on some of the unexplored questions in the field. We note that some of the material discussed is speculative in nature and is presented in order to motivate future work.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 145 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 17%
Student > Bachelor 21 14%
Researcher 18 12%
Student > Master 16 11%
Student > Doctoral Student 7 5%
Other 17 12%
Unknown 42 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 42 29%
Medicine and Dentistry 20 14%
Agricultural and Biological Sciences 15 10%
Immunology and Microbiology 7 5%
Mathematics 3 2%
Other 11 8%
Unknown 47 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2017.
All research outputs
#17,451,209
of 25,604,262 outputs
Outputs from Frontiers in oncology
#8,119
of 22,741 outputs
Outputs of similar age
#219,555
of 343,025 outputs
Outputs of similar age from Frontiers in oncology
#48
of 93 outputs
Altmetric has tracked 25,604,262 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,741 research outputs from this source. They receive a mean Attention Score of 3.0. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,025 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.