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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer
|
|---|---|
| Published in |
Frontiers in oncology, November 2017
|
| DOI | 10.3389/fonc.2017.00286 |
| Pubmed ID | |
| Authors |
Luisa Iommarini, Anna Maria Porcelli, Giuseppe Gasparre, Ivana Kurelac |
| Abstract |
Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers. Its canonical regulation involves prolyl hydroxylases (PHDs), which in normoxia induce degradation, whereas in hypoxia allow stabilization of HIF-1α. However, in certain circumstances, HIF-1α regulation goes beyond the actual external oxygen levels and involves PHD-independent mechanisms. Here, we gather and discuss the evidence on the non-canonical HIF-1α regulation, focusing in particular on the consequences of mitochondrial respiratory complexes damage on stabilization of this pleiotropic transcription factor. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 270 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 270 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 43 | 16% |
| Researcher | 39 | 14% |
| Student > Ph. D. Student | 37 | 14% |
| Student > Bachelor | 25 | 9% |
| Student > Doctoral Student | 15 | 6% |
| Other | 33 | 12% |
| Unknown | 78 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 86 | 32% |
| Medicine and Dentistry | 35 | 13% |
| Agricultural and Biological Sciences | 28 | 10% |
| Immunology and Microbiology | 13 | 5% |
| Chemistry | 7 | 3% |
| Other | 19 | 7% |
| Unknown | 82 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2018.
All research outputs
#15,173,117
of 25,382,440 outputs
Outputs from Frontiers in oncology
#4,551
of 22,428 outputs
Outputs of similar age
#231,339
of 446,465 outputs
Outputs of similar age from Frontiers in oncology
#31
of 82 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,428 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,465 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.