Title |
Plasma Lipidomic Signature of Rectal Adenocarcinoma Reveals Potential Biomarkers
|
---|---|
Published in |
Frontiers in oncology, January 2018
|
DOI | 10.3389/fonc.2017.00325 |
Pubmed ID | |
Authors |
Márcia Cristina Fernandes Messias, Giovana Colozza Mecatti, Célio Fernando Figueiredo Angolini, Marcos Nogueira Eberlin, Laura Credidio, Carlos Augusto Real Martinez, Cláudio Saddy Rodrigues Coy, Patrícia de Oliveira Carvalho |
Abstract |
Rectal adenocarcinoma (RAC) is a common malignant tumor of the digestive tract and survival is highly dependent upon stage of disease at diagnosis. Lipidomic strategy can be used to identify potential biomarkers for establishing early diagnosis or therapeutic programs for RAC. To evaluate the lipoperoxidation biomarkers and lipidomic signature in the plasma of patients with RAC (n = 23) and healthy controls (n = 18). Lipoperoxidation was evaluated based on malondialdehyde (MDA) and F2-isoprostane levels and the lipidomic profile obtained by gas chromatography and high resolution mass spectrometry (ESI-q-TOF) associated with a multivariate statistical technique. The most abundant ions identified in the RAC patients were those of protonated phosphatidylcholine and phosphatidylethanolamine. It was found that a lisophosphatidylcholine (LPC) plasmalogen containing palmitoleic acid [LPC (P-16:1)], with highest variable importance projection score, showed a tendency to be lower in the cancer patients. A reduction of n - 3 polyunsaturated fatty acids was observed in the plasma of these patients. MDA levels were higher in patients with advanced cancer (stages III/IV) than in the early stages groups and the healthy group (p < 0.05). No differences in F2-isoprostane levels were observed among these groups. This study shows that the reduction in plasma levels of LPC plasmalogens associated with an increase in MDA levels may indicate increased oxidative stress in these patients and identify the metabolite LPC (P-16:1) as a putatively novel lipid signature for RAC. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 23% |
Student > Master | 6 | 19% |
Student > Bachelor | 3 | 10% |
Student > Doctoral Student | 2 | 6% |
Professor > Associate Professor | 2 | 6% |
Other | 2 | 6% |
Unknown | 9 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 23% |
Chemistry | 4 | 13% |
Medicine and Dentistry | 4 | 13% |
Nursing and Health Professions | 1 | 3% |
Agricultural and Biological Sciences | 1 | 3% |
Other | 3 | 10% |
Unknown | 11 | 35% |