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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Role of BRCA Mutations in the Modulation of Response to Platinum Therapy
|
|---|---|
| Published in |
Frontiers in oncology, February 2018
|
| DOI | 10.3389/fonc.2018.00016 |
| Pubmed ID | |
| Authors |
Sanghamitra Mylavarapu, Asmita Das, Monideepa Roy |
| Abstract |
Recent years have seen cancer emerge as one of the leading cause of mortality worldwide with breast cancer being the second most common cause of death among women. Individuals harboring BRCA mutations are at a higher risk of developing breast and/or ovarian cancers. This risk is much greater in the presence of germline mutations. BRCA1 and BRCA2 play crucial role in the DNA damage response and repair pathway, a function that is critical in preserving the integrity of the genome. Mutations that interfere with normal cellular function of BRCA not only lead to onset and progression of cancer but also modulate therapy outcome of treatment with platinum drugs. In this review, we discuss the structural and functional impact of some of the prevalent BRCA mutations in breast and ovarian cancers and their role in platinum therapy response. Understanding the response of platinum drugs in the context of BRCA mutations may contribute toward developing better therapeutics that can improve survival and quality of life of patients. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 10% |
| United States | 2 | 10% |
| Brazil | 2 | 10% |
| Colombia | 1 | 5% |
| India | 1 | 5% |
| Switzerland | 1 | 5% |
| Unknown | 12 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 71% |
| Scientists | 4 | 19% |
| Practitioners (doctors, other healthcare professionals) | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 253 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 253 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 47 | 19% |
| Student > Ph. D. Student | 29 | 11% |
| Researcher | 22 | 9% |
| Student > Master | 18 | 7% |
| Student > Doctoral Student | 12 | 5% |
| Other | 32 | 13% |
| Unknown | 93 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 72 | 28% |
| Medicine and Dentistry | 34 | 13% |
| Agricultural and Biological Sciences | 12 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
| Immunology and Microbiology | 6 | 2% |
| Other | 19 | 8% |
| Unknown | 101 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2022.
All research outputs
#1,538,010
of 25,382,440 outputs
Outputs from Frontiers in oncology
#280
of 22,428 outputs
Outputs of similar age
#35,734
of 445,948 outputs
Outputs of similar age from Frontiers in oncology
#6
of 88 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,428 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,948 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.