Title |
A Cartography of Siglecs and Sialyltransferases in Gynecologic Malignancies: Is There a Road Towards a Sweet Future?
|
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Published in |
Frontiers in oncology, March 2018
|
DOI | 10.3389/fonc.2018.00068 |
Pubmed ID | |
Authors |
Quentin Haas, Cedric Simillion, Stephan von Gunten |
Abstract |
Altered surface glycosylation is a key feature of cancers, including gynecologic malignancies. Hypersialylation, the overexpression of sialic acid, is known to promote tumor progression and to dampen antitumor responses by mechanisms that also involve sialic acid binding immunoglobulin-like lectins (Siglecs), inhibitory immune receptors. Here, we discuss the expression patterns of Siglecs and sialyltransferases (STs) in gynecologic cancers, including breast, ovarian, and uterine malignancies, based on evidence from The Cancer Genome Atlas. The balance between sialosides generated by specific STs within the tumor microenvironment and Siglecs on leukocytes may play a decisive role for antitumor immunity. An interdisciplinary effort is required to decipher the characteristics and biological impact of the altered tumor sialome in gynecologic cancers and to exploit this knowledge to the clinical benefit of patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 19% |
Researcher | 5 | 14% |
Student > Ph. D. Student | 5 | 14% |
Other | 3 | 8% |
Student > Doctoral Student | 3 | 8% |
Other | 4 | 11% |
Unknown | 10 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 22% |
Biochemistry, Genetics and Molecular Biology | 7 | 19% |
Immunology and Microbiology | 4 | 11% |
Neuroscience | 2 | 5% |
Engineering | 2 | 5% |
Other | 2 | 5% |
Unknown | 12 | 32% |