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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alterations of the Human Skin N- and O-Glycome in Basal Cell Carcinoma and Squamous Cell Carcinoma
|
|---|---|
| Published in |
Frontiers in oncology, March 2018
|
| DOI | 10.3389/fonc.2018.00070 |
| Pubmed ID | |
| Authors |
Uwe Möginger, Sonja Grunewald, René Hennig, Chu-Wei Kuo, Falko Schirmeister, Harald Voth, Erdmann Rapp, Kay-Hooi Khoo, Peter H. Seeberger, Jan C. Simon, Daniel Kolarich |
| Abstract |
The glycome of one of the largest and most exposed human organs, the skin, as well as glycan changes associated with non-melanoma skin cancers have not been studied in detail to date. Skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are among the most frequent types of cancers with rising incidence rates in the aging population. We investigated the healthy human skinN- andO-glycome and its changes associated with BCC and SCC. Matched patient samples were obtained from frozen biopsy and formalin-fixed paraffin-embedded tissue samples for glycomics analyses using two complementary glycomics approaches: porous graphitized carbon nano-liquid chromatography electro spray ionization tandem mass spectrometry and capillary gel electrophoresis with laser induced fluorescence detection. The human skinN-glycome is dominated by complex typeN-glycans that exhibit almost similar levels of α2-3 and α2-6 sialylation. Fucose is attached exclusively to theN-glycan core. Core 1 and core 2 typeO-glycans carried up to three sialic acid residues. An increase of oligomannose typeN-glycans and core 2 typeO-glycans was observed in BCC and SCC, while α2-3 sialylation levels were decreased in SCC but not in BCC. Furthermore, glycopeptide analyses provided insights into the glycoprotein candidates possibly associated with the observedN-glycan changes, with glycoproteins associated with binding events being the most frequently identified class. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 3 | 13% |
| United States | 3 | 13% |
| Germany | 3 | 13% |
| Spain | 2 | 9% |
| Canada | 1 | 4% |
| Switzerland | 1 | 4% |
| Austria | 1 | 4% |
| United Kingdom | 1 | 4% |
| Croatia | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 6 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 65% |
| Scientists | 8 | 35% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 35% |
| Researcher | 5 | 12% |
| Other | 2 | 5% |
| Student > Bachelor | 2 | 5% |
| Student > Doctoral Student | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 14 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 23% |
| Medicine and Dentistry | 5 | 12% |
| Chemistry | 4 | 9% |
| Agricultural and Biological Sciences | 2 | 5% |
| Immunology and Microbiology | 2 | 5% |
| Other | 5 | 12% |
| Unknown | 15 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2022.
All research outputs
#2,164,491
of 25,523,622 outputs
Outputs from Frontiers in oncology
#478
of 22,634 outputs
Outputs of similar age
#45,675
of 347,967 outputs
Outputs of similar age from Frontiers in oncology
#16
of 124 outputs
Altmetric has tracked 25,523,622 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,634 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 347,967 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.