Title |
Discovering a Reliable Heat-Shock Factor-1 Inhibitor to Treat Human Cancers: Potential Opportunity for Phytochemists
|
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Published in |
Frontiers in oncology, April 2018
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DOI | 10.3389/fonc.2018.00097 |
Pubmed ID | |
Authors |
Murugesan Velayutham, Arturo J. Cardounel, Zhenguo Liu, Govindasamy Ilangovan |
Abstract |
Heat-shock factor-1 (HSF-1) is an important transcription factor that regulates pathogenesis of many human diseases through its extensive transcriptional regulation. Especially, it shows pleiotropic effects in human cancer, and hence it has recently received increased attention of cancer researchers. After myriad investigations on HSF-1, the field has advanced to the phase where there is consensus that finding a potent and selective pharmacological inhibitor for this transcription factor will be a major break-through in the treatment of various human cancers. Presently, all reported inhibitors have their limitations, made evident at different stages of clinical trials. This brief account summarizes the advances with tested natural products as HSF-1 inhibitors and highlights the necessity of phytochemistry in this endeavor of discovering a potent pharmacological HSF-1 inhibitor. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 25% |
Student > Master | 3 | 15% |
Researcher | 3 | 15% |
Professor | 1 | 5% |
Lecturer | 1 | 5% |
Other | 2 | 10% |
Unknown | 5 | 25% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 25% |
Biochemistry, Genetics and Molecular Biology | 3 | 15% |
Medicine and Dentistry | 3 | 15% |
Chemical Engineering | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Other | 3 | 15% |
Unknown | 4 | 20% |