Title |
Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids
|
---|---|
Published in |
Frontiers in oncology, April 2018
|
DOI | 10.3389/fonc.2018.00114 |
Pubmed ID | |
Authors |
Sayeda Yasmin-Karim, Michele Moreau, Romy Mueller, Neeharika Sinha, Raymond Dabney, Allen Herman, Wilfred Ngwa |
Abstract |
Over the years, many in vitro and in vivo studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations of combination therapy approaches that could better leverage these effects in clinical translation. This study explores the potential of combination approaches employing CBDs with radiotherapy (RT) or smart biomaterials toward enhancing therapeutic efficacy during treatment of pancreatic and lung cancers. In in vitro studies, clonogenic assay results showed greater effective tumor cell killing, when combining CBDs and RT. Meanwhile, in vivo study results revealed major increase in survival when employing smart biomaterials for sustained delivery of CBDs to tumor cells. The significance of these findings, considerations for further research, and viable roadmap to clinical translation are discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 7 | 17% |
Spain | 5 | 12% |
Portugal | 2 | 5% |
Colombia | 1 | 2% |
Argentina | 1 | 2% |
Ecuador | 1 | 2% |
Chile | 1 | 2% |
Jamaica | 1 | 2% |
Netherlands | 1 | 2% |
Other | 3 | 7% |
Unknown | 19 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 36 | 86% |
Practitioners (doctors, other healthcare professionals) | 4 | 10% |
Scientists | 2 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 89 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 15 | 17% |
Researcher | 11 | 12% |
Student > Ph. D. Student | 9 | 10% |
Student > Doctoral Student | 6 | 7% |
Other | 5 | 6% |
Other | 13 | 15% |
Unknown | 30 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 21% |
Biochemistry, Genetics and Molecular Biology | 11 | 12% |
Agricultural and Biological Sciences | 5 | 6% |
Veterinary Science and Veterinary Medicine | 5 | 6% |
Physics and Astronomy | 4 | 4% |
Other | 14 | 16% |
Unknown | 31 | 35% |