Title |
Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy
|
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Published in |
Frontiers in oncology, May 2018
|
DOI | 10.3389/fonc.2018.00164 |
Pubmed ID | |
Authors |
Tareq Saleh, Liliya Tyutynuk-Massey, Emmanuel K. Cudjoe, Michael O. Idowu, Joseph W. Landry, David A. Gewirtz |
Abstract |
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent an undesirable outcome of therapy by providing a mechanism for tumor dormancy and eventual disease recurrence. The senescence-associated secretory phenotype (SASP) is a hallmark of TIS and may contribute to aberrant effects of cancer therapy. Here, we propose that the SASP may also serve as a major driver of escape from senescence and the re-emergence of proliferating tumor cells, wherein factors secreted from the senescent cells contribute to the restoration of tumor growth in a non-cell autonomous fashion. Accordingly, anti-SASP therapies might serve to mitigate the deleterious outcomes of TIS. In addition to providing an overview of the putative actions of the SASP, we discuss recent efforts to identify and eliminate senescent tumor cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 98 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 20% |
Student > Master | 13 | 13% |
Researcher | 10 | 10% |
Student > Bachelor | 9 | 9% |
Student > Postgraduate | 5 | 5% |
Other | 14 | 14% |
Unknown | 27 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 39 | 40% |
Medicine and Dentistry | 7 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Immunology and Microbiology | 5 | 5% |
Agricultural and Biological Sciences | 5 | 5% |
Other | 6 | 6% |
Unknown | 31 | 32% |