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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics
|
|---|---|
| Published in |
Frontiers in oncology, May 2018
|
| DOI | 10.3389/fonc.2018.00174 |
| Pubmed ID | |
| Authors |
Shao Thing Teoh, Martin P. Ogrodzinski, Christina Ross, Kent W. Hunter, Sophia Y. Lunt |
| Abstract |
Metastatic breast cancer is currently incurable. It has recently emerged that different metabolic pathways support metastatic breast cancer. To further uncover metabolic pathways enabling breast cancer metastasis, we investigated metabolic differences in mouse tumors of differing metastatic propensities using mass spectrometry-based metabolomics. We found that sialic acid metabolism is upregulated in highly metastatic breast tumors. Knocking out a key gene in sialic acid metabolism, Cmas, inhibits synthesis of the activated form of sialic acid, cytidine monophosphate-sialic acid and decreases the formation of lung metastases in vivo. Thus, the sialic acid pathway may be a new target against metastatic breast cancer. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 10% |
| Switzerland | 1 | 10% |
| Belgium | 1 | 10% |
| Austria | 1 | 10% |
| Unknown | 6 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 60% |
| Scientists | 3 | 30% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 107 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 21% |
| Student > Ph. D. Student | 19 | 18% |
| Student > Master | 12 | 11% |
| Student > Bachelor | 10 | 9% |
| Student > Doctoral Student | 5 | 5% |
| Other | 10 | 9% |
| Unknown | 29 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 28% |
| Chemistry | 11 | 10% |
| Immunology and Microbiology | 8 | 7% |
| Agricultural and Biological Sciences | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Other | 15 | 14% |
| Unknown | 30 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2020.
All research outputs
#2,565,178
of 25,540,105 outputs
Outputs from Frontiers in oncology
#605
of 22,658 outputs
Outputs of similar age
#51,482
of 344,834 outputs
Outputs of similar age from Frontiers in oncology
#16
of 152 outputs
Altmetric has tracked 25,540,105 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,658 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,834 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 152 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.