Title |
Hypoxic Signalling in Tumour Stroma
|
---|---|
Published in |
Frontiers in oncology, May 2018
|
DOI | 10.3389/fonc.2018.00189 |
Pubmed ID | |
Authors |
Anu Laitala, Janine T. Erler |
Abstract |
Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The actual oxygen sensing is performed by HIF prolyl hydroxylases (PHDs) that under normoxic conditions mark the HIF-α subunit for degradation. Cancer progression is not regulated only by the cancer cells themselves but also by the whole tumor microenvironment, which consists of cellular and extracellular components. Hypoxic conditions also affect the stromal compartment, where stromal cells are in close contact with the cancer cells. The important function of HIF in cancer cells has been shown by many animal models and described in hundreds of reviews, but less in known about PHDs and even less PHDs in stromal cells. Here, we review hypoxic signaling in tumors, mainly in the tumor stroma, with a focus on HIFs and PHDs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 30% |
France | 2 | 20% |
Denmark | 1 | 10% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
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Scientists | 5 | 50% |
Members of the public | 5 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 59 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 12 | 20% |
Student > Master | 9 | 15% |
Student > Bachelor | 8 | 14% |
Student > Ph. D. Student | 8 | 14% |
Student > Doctoral Student | 5 | 8% |
Other | 6 | 10% |
Unknown | 11 | 19% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 20 | 34% |
Medicine and Dentistry | 9 | 15% |
Agricultural and Biological Sciences | 7 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Computer Science | 1 | 2% |
Other | 8 | 14% |
Unknown | 11 | 19% |