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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Fatty Acid Metabolism, Bone Marrow Adipocytes, and AML
|
|---|---|
| Published in |
Frontiers in oncology, February 2020
|
| DOI | 10.3389/fonc.2020.00155 |
| Pubmed ID | |
| Authors |
Yoko Tabe, Marina Konopleva, Michael Andreeff |
| Abstract |
Acute myeloid leukemia (AML) cells modulate their metabolic state continuously as a result of bone marrow (BM) microenvironment stimuli and/or nutrient availability. Adipocytes are prevalent in the BM stroma and increase in number with age. AML in elderly patients induces remodeling and lipolysis of BM adipocytes, which may promote AML cell survival through metabolic activation of fatty acid oxidation (FAO). FAO reactions generate acetyl-CoA from fatty acids under aerobic conditions and, under certain conditions, it can cause uncoupling of mitochondrial oxidative phosphorylation. Recent experimental evidence indicates that FAO is associated with quiescence and drug-resistance in leukemia stem cells. In this review, we highlight recent progress in our understanding of fatty acid metabolism in AML cells in the adipocyte-rich BM microenvironment, and discuss the therapeutic potential of combinatorial regimens with various FAO inhibitors, which target metabolic vulnerabilities of BM-resident, chemoresistant leukemia cells. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 83 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 17% |
| Student > Ph. D. Student | 13 | 16% |
| Student > Master | 10 | 12% |
| Student > Bachelor | 6 | 7% |
| Student > Doctoral Student | 4 | 5% |
| Other | 9 | 11% |
| Unknown | 27 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 37% |
| Medicine and Dentistry | 8 | 10% |
| Agricultural and Biological Sciences | 5 | 6% |
| Immunology and Microbiology | 3 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 28 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2020.
All research outputs
#14,924,082
of 25,387,668 outputs
Outputs from Frontiers in oncology
#4,144
of 22,433 outputs
Outputs of similar age
#192,156
of 382,814 outputs
Outputs of similar age from Frontiers in oncology
#114
of 493 outputs
Altmetric has tracked 25,387,668 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,433 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 382,814 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 493 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.