Title |
Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies
|
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Published in |
Frontiers in oncology, May 2021
|
DOI | 10.3389/fonc.2021.680834 |
Pubmed ID | |
Authors |
Yuming Zhao, Dengyang Zhang, Yao Guo, Bo Lu, Zhizhuang Joe Zhao, Xiaojun Xu, Yun Chen |
Abstract |
Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Studies have demonstrated that it plays an important role in oncogenesis by activating cell survival signaling events, particularly the non-canonical WNT signaling pathway. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes. However, small molecule inhibitors targeting ROR1 are underappreciated because of the initial characterization of ROR1 as a peusdokinase. The function of ROR1 as a tyrosine kinase remains poorly understood, although accumulating evidence have demonstrated its intrinsic tyrosine kinase activity. In this review, we analyzed the structural and functional features of ROR1 and discussed therapeutic strategies targeting this kinase. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 65 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 15% |
Student > Ph. D. Student | 6 | 9% |
Student > Master | 5 | 8% |
Other | 2 | 3% |
Student > Postgraduate | 2 | 3% |
Other | 4 | 6% |
Unknown | 36 | 55% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 11 | 17% |
Agricultural and Biological Sciences | 5 | 8% |
Immunology and Microbiology | 3 | 5% |
Chemistry | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 6% |
Unknown | 38 | 58% |