Title |
Targeting Immunometabolism in Glioblastoma
|
---|---|
Published in |
Frontiers in oncology, June 2021
|
DOI | 10.3389/fonc.2021.696402 |
Pubmed ID | |
Authors |
Aditya A Mohan, William H Tomaszewski, Aden P Haskell-Mendoza, Kelly M Hotchkiss, Kirit Singh, Jessica L Reedy, Peter E Fecci, John H Sampson, Mustafa Khasraw |
Abstract |
We have only recently begun to understand how cancer metabolism affects antitumor responses and immunotherapy outcomes. Certain immunometabolic targets have been actively pursued in other tumor types, however, glioblastoma research has been slow to exploit the therapeutic vulnerabilities of immunometabolism. In this review, we highlight the pathways that are most relevant to glioblastoma and focus on how these immunometabolic pathways influence tumor growth and immune suppression. We discuss hypoxia, glycolysis, tryptophan metabolism, arginine metabolism, 2-Hydroxyglutarate (2HG) metabolism, adenosine metabolism, and altered phospholipid metabolism, in order to provide an analysis and overview of the field of glioblastoma immunometabolism. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 33% |
Germany | 2 | 8% |
United Kingdom | 1 | 4% |
Switzerland | 1 | 4% |
Unknown | 12 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 16 | 67% |
Scientists | 5 | 21% |
Practitioners (doctors, other healthcare professionals) | 2 | 8% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 15% |
Student > Ph. D. Student | 5 | 13% |
Researcher | 4 | 10% |
Student > Doctoral Student | 2 | 5% |
Student > Bachelor | 2 | 5% |
Other | 3 | 8% |
Unknown | 17 | 44% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Medicine and Dentistry | 7 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
Agricultural and Biological Sciences | 1 | 3% |
Neuroscience | 1 | 3% |
Other | 2 | 5% |
Unknown | 18 | 46% |