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Mendeley readers
Attention Score in Context
| Title |
Metabolic reprogramming by miRNAs in the tumor microenvironment: Focused on immunometabolism
|
|---|---|
| Published in |
Frontiers in oncology, November 2022
|
| DOI | 10.3389/fonc.2022.1042196 |
| Pubmed ID | |
| Authors |
Shadia Hamoud Alshahrani, Yousif Saleh Ibrahim, Abduladheem Turki Jalil, Abdelgadir Alamin Altoum, Harun Achmad, Rahman S. Zabibah, Gamal A. Gabr, Andrés Alexis Ramírez-Coronel, Ameer A. Alameri, Qutaiba A. Qasim, Sajad Karampoor, Rasoul Mirzaei |
| Abstract |
MicroRNAs (miRNAs) are emerging as a significant modulator of immunity, and their abnormal expression/activity has been linked to numerous human disorders, such as cancer. It is now known that miRNAs potentially modulate the production of several metabolic processes in tumor-associated immune cells and indirectly via different metabolic enzymes that affect tumor-associated signaling cascades. For instance, Let-7 has been identified as a crucial modulator for the long-lasting survival of CD8+ T cells (naive phenotypes) in cancer by altering their metabolism. Furthermore, in T cells, it has been found that enhancer of zeste homolog 2 (EZH2) expression is controlled via glycolytic metabolism through miRNAs in patients with ovarian cancer. On the other hand, immunometabolism has shown us that cellular metabolic reactions and processes not only generate ATP and biosynthetic intermediates but also modulate the immune system and inflammatory processes. Based on recent studies, new and encouraging approaches to cancer involving the modification of miRNAs in immune cell metabolism are currently being investigated, providing insight into promising targets for therapeutic strategies based on the pivotal role of immunometabolism in cancer. Throughout this overview, we explore and describe the significance of miRNAs in cancer and immune cell metabolism. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 25% |
| Switzerland | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 1 | 25% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 20% |
| Unspecified | 2 | 20% |
| Professor > Associate Professor | 1 | 10% |
| Unknown | 5 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 2 | 20% |
| Biochemistry, Genetics and Molecular Biology | 2 | 20% |
| Neuroscience | 1 | 10% |
| Unknown | 5 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2022.
All research outputs
#15,417,750
of 25,872,466 outputs
Outputs from Frontiers in oncology
#4,554
of 22,820 outputs
Outputs of similar age
#212,053
of 493,542 outputs
Outputs of similar age from Frontiers in oncology
#299
of 1,505 outputs
Altmetric has tracked 25,872,466 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,820 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 493,542 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 1,505 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.