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Results of Treatment of Grades IV and V Vesicoureteral Reflux with Endoscopic Injection of Polyacrylate Polyalcohol Copolymer

Overview of attention for article published in Frontiers in Pediatrics, January 2013
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Title
Results of Treatment of Grades IV and V Vesicoureteral Reflux with Endoscopic Injection of Polyacrylate Polyalcohol Copolymer
Published in
Frontiers in Pediatrics, January 2013
DOI 10.3389/fped.2013.00032
Pubmed ID
Authors

Francisco Ignacio De Badiola, Ricardo Soria, Roberto Luis Vagni, María Nieves Ormaechea, Juan Manuel Moldes, César Benmaor

Abstract

Purpose: Here we report the results of a review of a prospectively maintained database of the use polyacrylate polyalcohol copolymer (PPC) injection to correct grades IV and V VUR. Materials and Methods: All children with grades IV and V primary VUR that presented with febrile urinary tract infection while on prophylaxis, in a 3-year period, were treated with a sub-ureteral injection of PPC. Institutional ethical approval was obtained. Exclusion criteria were incomplete bladder emptying documented on videourodynamic study, ureteral duplication, paraureteral diverticula, and poor ureteral emptying observed during fluoroscopy and previous open surgical or endoscopic treatment. Pre- and post-operative evaluation included urinalysis, renal and bladder ultrasonography, DMSA scan, and videourodynamic studies. Results: Thirty-three children [36 renal units (RU)] were included with a median age of 57 months (range 7-108). There were 18 boys and 15 girls. Thirty RU had grade IV and 6 grade V VUR. Median follow-up time was 32 months (range 7-58). Reflux was cured in 32/36 RU with the first injection, but another two patients were reimplanted because of dilatation. Complications included early urinary tract infection in seven children, transient lower urinary tract symptoms in five children. Progressive ureteral dilatation was noted in four children and was treated with insertion of a double J stent. Two of these children eventually required an ureteroneocystostomy. Conclusion: The use of PPC to treat grades IV and V vesicoureteral reflux in young children has an overall success rate of 83.3%. Persistent ureteral dilatation was present in 11% associated with high injection volume. Future studies will attempt to maintain a high success rate reducing the volume of injection and the incidence of dilatation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Other 4 16%
Student > Master 4 16%
Student > Bachelor 2 8%
Professor 2 8%
Student > Doctoral Student 2 8%
Other 6 24%
Unknown 5 20%
Readers by discipline Count As %
Medicine and Dentistry 11 44%
Nursing and Health Professions 3 12%
Agricultural and Biological Sciences 2 8%
Veterinary Science and Veterinary Medicine 1 4%
Neuroscience 1 4%
Other 0 0%
Unknown 7 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2013.
All research outputs
#20,207,295
of 22,727,570 outputs
Outputs from Frontiers in Pediatrics
#4,084
of 5,895 outputs
Outputs of similar age
#248,792
of 280,760 outputs
Outputs of similar age from Frontiers in Pediatrics
#24
of 46 outputs
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