Title |
Inflammatory Injury to the Neonatal Brain – What Can We Do?
|
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Published in |
Frontiers in Pediatrics, April 2014
|
DOI | 10.3389/fped.2014.00030 |
Pubmed ID | |
Authors |
Noa Ofek-Shlomai, Itai Berger |
Abstract |
Perinatal brain damage is one of the leading causes of life long disability. This damage could be hypoxic-ischemic, inflammatory, or both. This mini-review discusses different interventions aiming at minimizing inflammatory processes in the neonatal brain, both before and after insult. Current options of anti-inflammatory measures for neonates remain quite limited. We describe current anti-inflammatory intervention strategies such as avoiding perinatal infection and inflammation, and reducing exposure to inflammatory processes. We describe the known effects of anti-inflammatory drugs such as steroids, antibiotics, and indomethacin, and the possible anti-inflammatory role of other substances such as IL-1 receptor antagonists, erythropoietin, caffeine, estradiol, insulin-like growth factor, and melatonin as well as endogenous protectors, and genetic regulation of inflammation. If successful, these may decrease mortality and long-term morbidity among term and pre-term infants. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 3% |
Switzerland | 1 | 3% |
Unknown | 37 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 28% |
Student > Bachelor | 6 | 15% |
Student > Master | 5 | 13% |
Other | 4 | 10% |
Professor > Associate Professor | 2 | 5% |
Other | 3 | 8% |
Unknown | 8 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 23% |
Medicine and Dentistry | 9 | 23% |
Neuroscience | 5 | 13% |
Nursing and Health Professions | 2 | 5% |
Immunology and Microbiology | 2 | 5% |
Other | 3 | 8% |
Unknown | 9 | 23% |