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Alterations of Neocortical Pyramidal Neurons: Turning Points in the Genesis of Mental Retardation

Overview of attention for article published in Frontiers in Pediatrics, August 2014
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

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1 peer review site
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1 Facebook page

Citations

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36 Dimensions

Readers on

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17 Mendeley
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Title
Alterations of Neocortical Pyramidal Neurons: Turning Points in the Genesis of Mental Retardation
Published in
Frontiers in Pediatrics, August 2014
DOI 10.3389/fped.2014.00086
Pubmed ID
Authors

Alberto Granato, Andrea De Giorgio

Abstract

Pyramidal neurons (PNs) represent the majority of neocortical cells and their involvement in cognitive functions is decisive. Therefore, they are the most obvious target of developmental disorders characterized by mental retardation. Genetic and non-genetic forms of intellectual disability share a few basic pathogenetic signatures that result in the anomalous function of PNs. Here, we review the key mechanisms impairing these neurons and their participation in the cortical network, with special focus on experimental models of fetal exposure to alcohol. Due to the heterogeneity of PNs, some alterations affect selectively a given cell population, which may also differ depending on the considered pathology. These specific features open new possibilities for the interpretation of cognitive defects observed in mental retardation syndromes, as well as for novel therapeutic interventions.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 35%
Researcher 6 35%
Librarian 1 6%
Professor 1 6%
Student > Doctoral Student 1 6%
Other 2 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 41%
Neuroscience 3 18%
Medicine and Dentistry 2 12%
Immunology and Microbiology 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 2 12%
Unknown 1 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2014.
All research outputs
#14,782,907
of 22,758,963 outputs
Outputs from Frontiers in Pediatrics
#2,250
of 5,917 outputs
Outputs of similar age
#126,983
of 230,875 outputs
Outputs of similar age from Frontiers in Pediatrics
#16
of 38 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,917 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,875 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.