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Opsismodysplasia: Phosphate Wasting Osteodystrophy Responds to Bisphosphonate Therapy

Overview of attention for article published in Frontiers in Pediatrics, June 2015
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Title
Opsismodysplasia: Phosphate Wasting Osteodystrophy Responds to Bisphosphonate Therapy
Published in
Frontiers in Pediatrics, June 2015
DOI 10.3389/fped.2015.00048
Pubmed ID
Authors

Ansab Khwaja, Shawn E. Parnell, Kathryn Ness, Viviana Bompadre, Klane K. White

Abstract

We present two siblings affected with opsismodysplasia (OPS), a rare skeletal dysplasia caused by mutations in the inositol polyphosphate phosphatase-like 1 gene. The skeletal findings include short stature with postnatal onset micromelia, marked platyspondyly, squared metacarpals, delayed skeletal ossification, metaphyseal cupping, and postnatal micromelia. Respiratory compromise, delayed ambulation, and progressive lower extremity deformities are described. The severity of findings is variable. Renal phosphate wasting is associated with severe bone demineralization and a more severe phenotype. This report represents the first described cases of opsismodysplasia treated with intravenous bisphosphonate (pamidronate). Surgical management for lower extremity deformities associated with OPS is also reviewed. IV Case series.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 25%
Student > Doctoral Student 2 13%
Student > Bachelor 2 13%
Student > Ph. D. Student 2 13%
Professor 1 6%
Other 1 6%
Unknown 4 25%
Readers by discipline Count As %
Medicine and Dentistry 9 56%
Biochemistry, Genetics and Molecular Biology 3 19%
Agricultural and Biological Sciences 1 6%
Unknown 3 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2015.
All research outputs
#18,409,030
of 22,803,211 outputs
Outputs from Frontiers in Pediatrics
#3,342
of 5,952 outputs
Outputs of similar age
#189,481
of 263,797 outputs
Outputs of similar age from Frontiers in Pediatrics
#20
of 26 outputs
Altmetric has tracked 22,803,211 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,952 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,797 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.