Title |
Cerebral Palsy—Trends in Epidemiology and Recent Development in Prenatal Mechanisms of Disease, Treatment, and Prevention
|
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Published in |
Frontiers in Pediatrics, February 2017
|
DOI | 10.3389/fped.2017.00021 |
Pubmed ID | |
Authors |
Moshe Stavsky, Omer Mor, Salvatore Andrea Mastrolia, Shirley Greenbaum, Nandor Gabor Than, Offer Erez |
Abstract |
Cerebral palsy (CP) is the most common motor disability in childhood. This syndrome is the manifestation of intrauterine pathologies, intrapartum complications, and the postnatal sequel, especially among preterm neonates. A double hit model theory is proposed suggesting that an intrauterine condition along with intrapartum or postnatal insult lead to the development of CP. Recent reports demonstrated that treatment during the process of preterm birth such as magnesium sulfate and postnatal modalities such as cooling may prevent or reduce the prevalence of this syndrome. Moreover, animal models demonstrated that postnatal treatment with anti-inflammatory drugs coupled with nanoparticles may affect the course of the disease in pups with neuroinflammation. This review will describe the changes in the epidemiology of this disease, the underlying prenatal mechanisms, and possible treatments that may reduce the prevalence of CP and alter the course of the disease. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 25% |
Philippines | 1 | 25% |
United States | 1 | 25% |
Switzerland | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 773 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 143 | 18% |
Student > Master | 97 | 13% |
Researcher | 43 | 6% |
Student > Postgraduate | 42 | 5% |
Student > Ph. D. Student | 34 | 4% |
Other | 104 | 13% |
Unknown | 310 | 40% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 171 | 22% |
Nursing and Health Professions | 123 | 16% |
Neuroscience | 38 | 5% |
Engineering | 33 | 4% |
Psychology | 17 | 2% |
Other | 67 | 9% |
Unknown | 324 | 42% |