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IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature

Overview of attention for article published in Frontiers in Pediatrics, April 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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1 policy source
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1 X user

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35 Mendeley
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Title
IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature
Published in
Frontiers in Pediatrics, April 2017
DOI 10.3389/fped.2017.00083
Pubmed ID
Authors

Karina Gobin, Mary Hintermeyer, Bertrand Boisson, Maya Chrabieh, Pegah Ghandil, Anne Puel, Capucine Picard, Jean-Laurent Casanova, John Routes, James Verbsky

Abstract

Primary immunodeficiencies are genetic defects of the innate or adaptive immune system, resulting in a propensity to infections. The innate immune system is the first line of defense against pathogens and is critical to recognize microbes and start the inflammatory cascade. Sensing of microbes occurs by a number of pathogen-recognition receptors, resulting in the activation of inflammatory signal transduction pathways, such as the activation of NF-κB. Herein, we describe a case of IRAK4 deficiency, a key signal transduction molecule of toll-like and IL-1 receptors. We highlight the complexities in diagnosis of these disorders and review genetic defects of the NF-κB pathway.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 17%
Student > Ph. D. Student 6 17%
Student > Doctoral Student 3 9%
Student > Bachelor 3 9%
Student > Master 3 9%
Other 7 20%
Unknown 7 20%
Readers by discipline Count As %
Medicine and Dentistry 12 34%
Biochemistry, Genetics and Molecular Biology 8 23%
Immunology and Microbiology 4 11%
Chemistry 1 3%
Unknown 10 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2019.
All research outputs
#7,278,876
of 22,968,808 outputs
Outputs from Frontiers in Pediatrics
#1,284
of 6,027 outputs
Outputs of similar age
#115,312
of 310,521 outputs
Outputs of similar age from Frontiers in Pediatrics
#30
of 85 outputs
Altmetric has tracked 22,968,808 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 6,027 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,521 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.