Title |
The Centenary of Immune Thrombocytopenia—Part 2: Revising Diagnostic and Therapeutic Approach
|
---|---|
Published in |
Frontiers in Pediatrics, August 2017
|
DOI | 10.3389/fped.2017.00179 |
Pubmed ID | |
Authors |
Rita Consolini, Giorgio Costagliola, Davide Spatafora |
Abstract |
Primary immune thrombocytopenia (ITP) is the most common cause of thrombocytopenia in children and adolescents and can be considered as a paradigmatic model of autoimmune disease. This second part of our review describes the clinical presentation of ITP, the diagnostic approach and overviews the current therapeutic strategies. Interestingly, it suggests an algorithm useful for differential diagnosis, a crucial process to exclude secondary forms of immune thrombocytopenia (IT) and non-immune thrombocytopenia (non-IT), which require a different therapeutic management. Advances in understanding the pathogenesis led to new therapeutic targets, as thrombopoietin receptor agonists, whose role in treatment of ITP will be discussed in this work. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 7 | 16% |
Student > Bachelor | 5 | 12% |
Researcher | 4 | 9% |
Student > Postgraduate | 4 | 9% |
Student > Master | 4 | 9% |
Other | 7 | 16% |
Unknown | 12 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 40% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Nursing and Health Professions | 3 | 7% |
Physics and Astronomy | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 9% |
Unknown | 12 | 28% |