Title |
Prenatal Maternal Stress and the Risk of Asthma in Children
|
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Published in |
Frontiers in Pediatrics, September 2017
|
DOI | 10.3389/fped.2017.00202 |
Pubmed ID | |
Authors |
Konstantinos Douros, Maria Moustaki, Sophia Tsabouri, Anna Papadopoulou, Marios Papadopoulos, Kostas N. Priftis |
Abstract |
Emerging evidence indicate that maternal prenatal stress (MPS) can result in a range of long-term adverse effects in the offspring. The underlying mechanism of MPS is not fully understood. However, its complexity is emphasized by the number of purportedly involved pathways namely, placental deregulated metabolism of maternal steroids, impaired maturation of fetal HPA axis, imbalanced efflux of commensal bacteria across the placenta, and skewed immune development toward Th2. Fetal programming probably exerts a pivotal role in the end result of the above pathways through the modulation of gene expression. In this review, we highlight the current knowledge from epidemiological and experimental studies regarding the effects of MPS on asthma development in the offspring. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 14% |
Switzerland | 1 | 14% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 82 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 15% |
Student > Bachelor | 12 | 15% |
Researcher | 8 | 10% |
Student > Doctoral Student | 5 | 6% |
Student > Postgraduate | 4 | 5% |
Other | 14 | 17% |
Unknown | 27 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 24% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Nursing and Health Professions | 7 | 9% |
Psychology | 6 | 7% |
Agricultural and Biological Sciences | 5 | 6% |
Other | 11 | 13% |
Unknown | 26 | 32% |