Title |
Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells
|
---|---|
Published in |
Frontiers in Pediatrics, April 2018
|
DOI | 10.3389/fped.2018.00082 |
Pubmed ID | |
Authors |
Elizabeth A. LaMarca, Samuel K. Powell, Schahram Akbarian, Kristen J. Brennand |
Abstract |
Human-induced pluripotent stem cells (hiPSCs) have revolutionized our ability to model neuropsychiatric and neurodegenerative diseases, and recent progress in the field is paving the way for improved therapeutics. In this review, we discuss major advances in generating hiPSC-derived neural cells and cutting-edge techniques that are transforming hiPSC technology, such as three-dimensional "mini-brains" and clustered, regularly interspersed short palindromic repeats (CRISPR)-Cas systems. We examine specific examples of how hiPSC-derived neural cells are being used to uncover the pathophysiology of schizophrenia and Parkinson's disease, and consider the future of this groundbreaking research. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 115 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 20% |
Researcher | 16 | 14% |
Student > Bachelor | 15 | 13% |
Student > Master | 14 | 12% |
Other | 6 | 5% |
Other | 13 | 11% |
Unknown | 28 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 31 | 27% |
Biochemistry, Genetics and Molecular Biology | 26 | 23% |
Agricultural and Biological Sciences | 10 | 9% |
Medicine and Dentistry | 6 | 5% |
Engineering | 3 | 3% |
Other | 8 | 7% |
Unknown | 31 | 27% |