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Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells

Overview of attention for article published in Frontiers in Pediatrics, April 2018
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Title
Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells
Published in
Frontiers in Pediatrics, April 2018
DOI 10.3389/fped.2018.00082
Pubmed ID
Authors

Elizabeth A. LaMarca, Samuel K. Powell, Schahram Akbarian, Kristen J. Brennand

Abstract

Human-induced pluripotent stem cells (hiPSCs) have revolutionized our ability to model neuropsychiatric and neurodegenerative diseases, and recent progress in the field is paving the way for improved therapeutics. In this review, we discuss major advances in generating hiPSC-derived neural cells and cutting-edge techniques that are transforming hiPSC technology, such as three-dimensional "mini-brains" and clustered, regularly interspersed short palindromic repeats (CRISPR)-Cas systems. We examine specific examples of how hiPSC-derived neural cells are being used to uncover the pathophysiology of schizophrenia and Parkinson's disease, and consider the future of this groundbreaking research.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 115 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 20%
Researcher 16 14%
Student > Bachelor 15 13%
Student > Master 14 12%
Other 6 5%
Other 13 11%
Unknown 28 24%
Readers by discipline Count As %
Neuroscience 31 27%
Biochemistry, Genetics and Molecular Biology 26 23%
Agricultural and Biological Sciences 10 9%
Medicine and Dentistry 6 5%
Engineering 3 3%
Other 8 7%
Unknown 31 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2018.
All research outputs
#15,503,317
of 23,039,416 outputs
Outputs from Frontiers in Pediatrics
#2,677
of 6,105 outputs
Outputs of similar age
#209,927
of 329,118 outputs
Outputs of similar age from Frontiers in Pediatrics
#72
of 114 outputs
Altmetric has tracked 23,039,416 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,105 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,118 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.