Title |
The Prospective Role of Plant Products in Radiotherapy of Cancer: A Current Overview
|
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Published in |
Frontiers in Pharmacology, January 2012
|
DOI | 10.3389/fphar.2011.00094 |
Pubmed ID | |
Authors |
Banasri Hazra, Subhalakshmi Ghosh, Amit Kumar, B. N. Pandey |
Abstract |
Treatment of cancer often requires exposure to radiation, which has several limitations involving non-specific toxicity toward normal cells, reducing the efficacy of treatment. Efforts are going on to find chemical compounds which would effectively offer protection to the normal tissues after radiation exposure during radiotherapy of cancer. In this regard, plant-derived compounds might serve as "leads" to design ideal radioprotectors/radiosensitizers. This article reviews some of the recent findings on prospective medicinal plants, phytochemicals, and their analogs, based on both in vitro and in vivo tumor models especially focused with relevance to cancer radiotherapy. Also, pertinent discussion has been presented on the molecular mechanism of apoptotic death in relation to the oxidative stress in cancer cells induced by some of these plant samples and their active constituents. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Lebanon | 1 | <1% |
United States | 1 | <1% |
Unknown | 102 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 19% |
Researcher | 16 | 15% |
Student > Master | 13 | 13% |
Student > Bachelor | 6 | 6% |
Other | 6 | 6% |
Other | 17 | 16% |
Unknown | 26 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 20% |
Medicine and Dentistry | 15 | 14% |
Biochemistry, Genetics and Molecular Biology | 15 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 8% |
Chemistry | 4 | 4% |
Other | 7 | 7% |
Unknown | 34 | 33% |