Title |
Primary Phagocytosis of Neurons by Inflamed Microglia: Potential Roles in Neurodegeneration
|
---|---|
Published in |
Frontiers in Pharmacology, January 2012
|
DOI | 10.3389/fphar.2012.00027 |
Pubmed ID | |
Authors |
Jonas J. Neher, Urte Neniskyte, Guy C. Brown |
Abstract |
Microglial phagocytosis of dead or dying neurons can be beneficial by preventing the release of damaging and/or pro-inflammatory intracellular components. However, there is now evidence that under certain conditions, such as inflammation, microglia can also phagocytose viable neurons, thus executing their death. Such phagocytic cell death may result from exposure of phosphatidylserine (PS) or other eat-me signals on otherwise viable neurons as a result of physiological activation or sub-toxic insult, and neuronal phagocytosis by activated microglia. In this review, we discuss the mechanisms of phagocytic cell death and its potential roles in Alzheimer's Disease, Parkinson's Disease, and Frontotemporal Dementia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Luxembourg | 2 | 1% |
United States | 2 | 1% |
Canada | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Unknown | 163 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 35 | 21% |
Student > Ph. D. Student | 32 | 19% |
Student > Bachelor | 27 | 16% |
Student > Master | 19 | 11% |
Student > Doctoral Student | 8 | 5% |
Other | 18 | 11% |
Unknown | 31 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 52 | 31% |
Neuroscience | 25 | 15% |
Medicine and Dentistry | 20 | 12% |
Biochemistry, Genetics and Molecular Biology | 18 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 15 | 9% |
Unknown | 36 | 21% |