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Mendeley readers
Attention Score in Context
| Title |
Protective Roles for Potassium SK/KCa2 Channels in Microglia and Neurons
|
|---|---|
| Published in |
Frontiers in Pharmacology, January 2012
|
| DOI | 10.3389/fphar.2012.00196 |
| Pubmed ID | |
| Authors |
Amalia M. Dolga, Carsten Culmsee |
| Abstract |
New concepts on potassium channel function in neuroinflammation suggest that they regulate mechanisms of microglial activation, including intracellular calcium homeostasis, morphological alterations, pro-inflammatory cytokine release, antigen presentation, and phagocytosis. Although little is known about voltage independent potassium channels in microglia, special attention emerges on small (SK/KCNN1-3/K(Ca)2) and intermediate (IK/KCNN4/K(Ca)3.1)-conductance calcium-activated potassium channels as regulators of microglial activation in the field of research on neuroinflammation and neurodegeneration. In particular, recent findings suggested that SK/K(Ca)2 channels, by regulating calcium homeostasis, may elicit a dual mechanism of action with protective properties in neurons and inhibition of inflammatory responses in microglia. Thus, modulating SK/K(Ca)2 channels and calcium signaling may provide novel therapeutic strategies in neurological disorders, where neuronal cell death and inflammatory responses concomitantly contribute to disease progression. Here, we review the particular role of SK/K(Ca)2 channels for [Ca(2+)](i) regulation in microglia and neurons, and we discuss the potential impact for further experimental approaches addressing novel therapeutic strategies in neurological diseases, where neuronal cell death and neuroinflammatory processes are prominent. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 59 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 20% |
| Student > Ph. D. Student | 11 | 18% |
| Student > Bachelor | 11 | 18% |
| Student > Master | 6 | 10% |
| Professor > Associate Professor | 5 | 8% |
| Other | 8 | 13% |
| Unknown | 7 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 32% |
| Agricultural and Biological Sciences | 17 | 28% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Medicine and Dentistry | 4 | 7% |
| Arts and Humanities | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 7 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2012.
All research outputs
#20,174,175
of 22,687,320 outputs
Outputs from Frontiers in Pharmacology
#9,894
of 15,880 outputs
Outputs of similar age
#221,217
of 244,125 outputs
Outputs of similar age from Frontiers in Pharmacology
#96
of 137 outputs
Altmetric has tracked 22,687,320 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 15,880 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,125 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.