Title |
Translational Concepts of mGluR5 in Synaptic Diseases of the Brain
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Published in |
Frontiers in Pharmacology, January 2012
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DOI | 10.3389/fphar.2012.00199 |
Pubmed ID | |
Authors |
Thomas M. Piers, Dong Hyun Kim, Byeong C. Kim, Philip Regan, Daniel J. Whitcomb, Kwangwook Cho |
Abstract |
The G-protein coupled receptor family of glutamate receptors, termed metabotropic glutamate receptors (mGluRs), are implicated in numerous cellular mechanisms ranging from neural development to the processing of cognitive, sensory, and motor information. Over the last decade, multiple mGluR-related signal cascades have been identified at excitatory synapses, indicating their potential roles in various forms of synaptic function and dysfunction. This review highlights recent studies investigating mGluR5, a subtype of group I mGluRs, and its association with a number of developmental, psychiatric, and senile synaptic disorders with respect to associated synaptic proteins, with an emphasis on translational pre-clinical studies targeting mGluR5 in a range of synaptic diseases of the brain. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 3% |
United Kingdom | 1 | <1% |
Japan | 1 | <1% |
Kazakhstan | 1 | <1% |
Unknown | 135 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 34 | 24% |
Researcher | 33 | 23% |
Student > Master | 18 | 13% |
Student > Bachelor | 13 | 9% |
Student > Postgraduate | 6 | 4% |
Other | 13 | 9% |
Unknown | 25 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 50 | 35% |
Neuroscience | 25 | 18% |
Medicine and Dentistry | 14 | 10% |
Biochemistry, Genetics and Molecular Biology | 12 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Other | 8 | 6% |
Unknown | 27 | 19% |