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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mechanisms and insights into drug resistance in cancer
|
|---|---|
| Published in |
Frontiers in Pharmacology, January 2013
|
| DOI | 10.3389/fphar.2013.00028 |
| Pubmed ID | |
| Authors |
Hiba Zahreddine, Katherine L. B. Borden |
| Abstract |
Cancer drug resistance continues to be a major impediment in medical oncology. Clinically, resistance can arise prior to or as a result of cancer therapy. In this review, we discuss different mechanisms adapted by cancerous cells to resist treatment, including alteration in drug transport and metabolism, mutation and amplification of drug targets, as well as genetic rewiring which can lead to impaired apoptosis. Tumor heterogeneity may also contribute to resistance, where small subpopulations of cells may acquire or stochastically already possess some of the features enabling them to emerge under selective drug pressure. Making the problem even more challenging, some of these resistance pathways lead to multidrug resistance, generating an even more difficult clinical problem to overcome. We provide examples of these mechanisms and some insights into how understanding these processes can influence the next generation of cancer therapies. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 783 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | <1% |
| India | 2 | <1% |
| Netherlands | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Russia | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Luxembourg | 1 | <1% |
| Poland | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 772 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 167 | 21% |
| Student > Master | 125 | 16% |
| Student > Bachelor | 99 | 13% |
| Researcher | 59 | 8% |
| Student > Doctoral Student | 47 | 6% |
| Other | 115 | 15% |
| Unknown | 171 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 193 | 25% |
| Agricultural and Biological Sciences | 144 | 18% |
| Medicine and Dentistry | 75 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 50 | 6% |
| Chemistry | 49 | 6% |
| Other | 81 | 10% |
| Unknown | 191 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2022.
All research outputs
#2,834,185
of 24,452,844 outputs
Outputs from Frontiers in Pharmacology
#1,138
of 18,439 outputs
Outputs of similar age
#28,328
of 289,929 outputs
Outputs of similar age from Frontiers in Pharmacology
#16
of 167 outputs
Altmetric has tracked 24,452,844 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,439 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,929 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 167 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.