Title |
The use of lipid-based nanocarriers for targeted pain therapies
|
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Published in |
Frontiers in Pharmacology, January 2013
|
DOI | 10.3389/fphar.2013.00143 |
Pubmed ID | |
Authors |
Susan Hua, Sherry Y. Wu |
Abstract |
Sustained delivery of analgesic agents at target sites remains a critical issue for effective pain management. The use of nanocarriers has been reported to facilitate effective delivery of these agents to target sites while minimizing systemic toxicity. These include the use of biodegradable liposomal or polymeric carriers. Of these, liposomes present as an attractive delivery system due to their flexible physicochemical properties which allow easy manipulation in order to address different delivery considerations. Their favorable toxicity profiles and ease of large scale production also make their clinical use feasible. In this review, we will discuss the concept of using liposomes as a drug delivery carrier, their in vitro characteristics as well as in vivo behavior. Current advances in the targeted liposomal delivery of analgesic agents and their impacts on the field of pain management will be presented. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | <1% |
France | 1 | <1% |
Unknown | 318 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 59 | 18% |
Student > Master | 53 | 17% |
Student > Bachelor | 48 | 15% |
Researcher | 17 | 5% |
Student > Doctoral Student | 14 | 4% |
Other | 37 | 12% |
Unknown | 92 | 29% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 48 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 46 | 14% |
Medicine and Dentistry | 25 | 8% |
Agricultural and Biological Sciences | 24 | 8% |
Chemistry | 19 | 6% |
Other | 54 | 17% |
Unknown | 104 | 33% |