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Mendeley readers
Attention Score in Context
| Title |
Label-free drug discovery
|
|---|---|
| Published in |
Frontiers in Pharmacology, March 2014
|
| DOI | 10.3389/fphar.2014.00052 |
| Pubmed ID | |
| Authors |
Ye Fang |
| Abstract |
Current drug discovery is dominated by label-dependent molecular approaches, which screen drugs in the context of a predefined and target-based hypothesis in vitro. Given that target-based discovery has not transformed the industry, phenotypic screen that identifies drugs based on a specific phenotype of cells, tissues, or animals has gained renewed interest. However, owing to the intrinsic complexity in drug-target interactions, there is often a significant gap between the phenotype screened and the ultimate molecular mechanism of action sought. This paper presents a label-free strategy for early drug discovery. This strategy combines label-free cell phenotypic profiling with computational approaches, and holds promise to bridge the gap by offering a kinetic and holistic representation of the functional consequences of drugs in disease relevant cells that is amenable to mechanistic deconvolution. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 3% |
| United States | 1 | 1% |
| Unknown | 85 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 27% |
| Researcher | 16 | 18% |
| Student > Master | 15 | 17% |
| Student > Doctoral Student | 7 | 8% |
| Student > Bachelor | 4 | 4% |
| Other | 11 | 12% |
| Unknown | 12 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 14 | 16% |
| Biochemistry, Genetics and Molecular Biology | 13 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 13% |
| Agricultural and Biological Sciences | 10 | 11% |
| Engineering | 8 | 9% |
| Other | 17 | 19% |
| Unknown | 15 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2021.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Frontiers in Pharmacology
#8,471
of 19,717 outputs
Outputs of similar age
#166,548
of 238,079 outputs
Outputs of similar age from Frontiers in Pharmacology
#33
of 70 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 19,717 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,079 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.