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Numerical Modeling Calcium and CaMKII Effects in the SA Node

Overview of attention for article published in Frontiers in Pharmacology, April 2014
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Title
Numerical Modeling Calcium and CaMKII Effects in the SA Node
Published in
Frontiers in Pharmacology, April 2014
DOI 10.3389/fphar.2014.00058
Pubmed ID
Authors

Yael Yaniv, Victor A. Maltsev

Abstract

Sinoatrial node (SAN) is the primary heart pacemaker which initiates each heartbeat under normal conditions. Numerous experimental data have demonstrated that Ca(2+-) and CaMKII-dependent processes are crucially important for regulation of SAN cells. However, specific mechanisms of this regulation and their relative contribution to pacemaker function remain mainly unknown. Our review summarizes available data and existing numerical modeling approaches to understand Ca(2+) and CaMKII effects on the SAN. Data interpretation and future directions to address the problem are given within the coupled-clock theory, i.e., a modern view on the cardiac pacemaker cell function generated by a system of sarcolemmal and intracellular proteins.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 16%
Student > Ph. D. Student 3 16%
Professor 3 16%
Other 2 11%
Lecturer 1 5%
Other 3 16%
Unknown 4 21%
Readers by discipline Count As %
Medicine and Dentistry 6 32%
Engineering 2 11%
Agricultural and Biological Sciences 2 11%
Unspecified 1 5%
Physics and Astronomy 1 5%
Other 1 5%
Unknown 6 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2014.
All research outputs
#20,226,756
of 22,751,628 outputs
Outputs from Frontiers in Pharmacology
#9,977
of 16,003 outputs
Outputs of similar age
#193,272
of 226,111 outputs
Outputs of similar age from Frontiers in Pharmacology
#46
of 74 outputs
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So far Altmetric has tracked 16,003 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.