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Pathophysiology of the Belgrade rat

Overview of attention for article published in Frontiers in Pharmacology, April 2014
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Title
Pathophysiology of the Belgrade rat
Published in
Frontiers in Pharmacology, April 2014
DOI 10.3389/fphar.2014.00082
Pubmed ID
Authors

Tania Veuthey, Marianne Wessling-Resnick

Abstract

The Belgrade rat is an animal model of divalent metal transporter 1 (DMT1) deficiency. This strain originates from an X-irradiation experiment first reported in 1966. Since then, the Belgrade rat's pathophysiology has helped to reveal the importance of iron balance and the role of DMT1. This review discusses our current understanding of iron transport homeostasis and summarizes molecular details of DMT1 function. We describe how studies of the Belgrade rat have revealed key roles for DMT1 in iron distribution to red blood cells as well as duodenal iron absorption. The Belgrade rat's pathology has extended our knowledge of hepatic iron handling, pulmonary and olfactory iron transport as well as brain iron uptake and renal iron handling. For example, relationships between iron and manganese metabolism have been discerned since both are essential metals transported by DMT1. Pathophysiologic features of the Belgrade rat provide us with a unique and interesting animal model to understand iron homeostasis.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 27%
Student > Master 5 19%
Researcher 4 15%
Student > Bachelor 2 8%
Professor 1 4%
Other 3 12%
Unknown 4 15%
Readers by discipline Count As %
Medicine and Dentistry 7 27%
Agricultural and Biological Sciences 6 23%
Biochemistry, Genetics and Molecular Biology 5 19%
Social Sciences 1 4%
Neuroscience 1 4%
Other 1 4%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2014.
All research outputs
#20,228,822
of 22,754,104 outputs
Outputs from Frontiers in Pharmacology
#9,979
of 16,008 outputs
Outputs of similar age
#193,187
of 226,936 outputs
Outputs of similar age from Frontiers in Pharmacology
#59
of 86 outputs
Altmetric has tracked 22,754,104 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,008 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.