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Mechanisms of iron metabolism in Caenorhabditis elegans

Overview of attention for article published in Frontiers in Pharmacology, May 2014
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Title
Mechanisms of iron metabolism in Caenorhabditis elegans
Published in
Frontiers in Pharmacology, May 2014
DOI 10.3389/fphar.2014.00113
Pubmed ID
Authors

Cole P. Anderson, Elizabeth A. Leibold

Abstract

Iron is involved in many biological processes essential for sustaining life. In excess, iron is toxic due to its ability to catalyze the formation of free radicals that damage macromolecules. Organisms have developed specialized mechanisms to tightly regulate iron uptake, storage and efflux. Over the past decades, vertebrate model organisms have led to the identification of key genes and pathways that regulate systemic and cellular iron metabolism. This review provides an overview of iron metabolism in the roundworm Caenorhabditis elegans and highlights recent studies on the role of hypoxia and insulin signaling in the regulation of iron metabolism. Given that iron, hypoxia and insulin signaling pathways are evolutionarily conserved, C. elegans provides a genetic model organism that promises to provide new insights into mechanisms regulating mammalian iron metabolism.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 64 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 20%
Researcher 10 16%
Student > Bachelor 9 14%
Student > Doctoral Student 4 6%
Student > Master 4 6%
Other 8 13%
Unknown 16 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 25%
Biochemistry, Genetics and Molecular Biology 12 19%
Neuroscience 6 9%
Immunology and Microbiology 4 6%
Environmental Science 2 3%
Other 7 11%
Unknown 17 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2014.
All research outputs
#14,781,203
of 22,756,196 outputs
Outputs from Frontiers in Pharmacology
#5,150
of 16,008 outputs
Outputs of similar age
#126,751
of 226,345 outputs
Outputs of similar age from Frontiers in Pharmacology
#33
of 76 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,008 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,345 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.