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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Prenatal transplantation of mesenchymal stem cells to treat osteogenesis imperfecta
|
|---|---|
| Published in |
Frontiers in Pharmacology, October 2014
|
| DOI | 10.3389/fphar.2014.00223 |
| Pubmed ID | |
| Authors |
Jerry K. Y. Chan, Cecilia Götherström |
| Abstract |
Osteogenesis imperfecta (OI) can be a severe disorder that can be diagnosed before birth. Transplantation of mesenchymal stem cells (MSC) has the potential to improve the bone structure, growth, and fracture healing. In this review, we give an introduction to OI and MSC, and the basis for pre- and postnatal transplantation in OI. We also summarize the two patients with OI who have received pre- and postnatal transplantation of MSC. The findings suggest that prenatal transplantation of allogeneic MSC in OI is safe. The cell therapy is of likely clinical benefit with improved linear growth, mobility, and reduced fracture incidence. Unfortunately, the effect is transient. For this reason, postnatal booster infusions using same-donor MSC have been performed with clinical benefit, and without any adverse events. So far there is limited experience in this specific field and proper studies are required to accurately conclude on clinical benefits of MSC transplantation to treat OI. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 2% |
| Unknown | 47 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 21% |
| Student > Bachelor | 8 | 17% |
| Student > Ph. D. Student | 6 | 13% |
| Researcher | 5 | 10% |
| Other | 5 | 10% |
| Other | 9 | 19% |
| Unknown | 5 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 31% |
| Biochemistry, Genetics and Molecular Biology | 11 | 23% |
| Agricultural and Biological Sciences | 8 | 17% |
| Chemistry | 2 | 4% |
| Unspecified | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 10 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2021.
All research outputs
#3,662,671
of 22,765,347 outputs
Outputs from Frontiers in Pharmacology
#1,567
of 16,009 outputs
Outputs of similar age
#42,071
of 255,208 outputs
Outputs of similar age from Frontiers in Pharmacology
#4
of 50 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,009 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,208 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.