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Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances

Overview of attention for article published in Frontiers in Pharmacology, December 2014
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Title
Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances
Published in
Frontiers in Pharmacology, December 2014
DOI 10.3389/fphar.2014.00273
Pubmed ID
Authors

Li Liu, Xiao-Dong Liu

Abstract

Diabetes is a systematic metabolic disease, which often develops a number of well-recognized vascular complications including brain complications which may partly result from the dysfunction of blood-brain barrier (BBB). BBB is generally considered as a mechanism for protecting the brain from unwanted actions resulting from substances in the blood and maintaining brain homeostasis via monitoring the entry or efflux of compounds. ATP-binding cassette (ABC) family of transporters including P-glycoprotein (P-GP) and breast cancer-related protein (BCRP), widely expressed in the luminal membrane of the microvessel endothelium and in the apical membrane of the choroids plexus epithelium, play important roles in the function of BBB. However, these transporters are easily altered by some diseases. The present article was focused on the alteration in expression and function of both P-GP and BCRP at BBB by diabetes and the clinical significances.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 3%
Germany 1 3%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 23%
Student > Master 7 18%
Other 4 10%
Student > Ph. D. Student 4 10%
Student > Bachelor 3 8%
Other 4 10%
Unknown 8 21%
Readers by discipline Count As %
Medicine and Dentistry 7 18%
Pharmacology, Toxicology and Pharmaceutical Science 5 13%
Agricultural and Biological Sciences 5 13%
Biochemistry, Genetics and Molecular Biology 3 8%
Immunology and Microbiology 2 5%
Other 7 18%
Unknown 10 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2022.
All research outputs
#20,076,137
of 24,677,985 outputs
Outputs from Frontiers in Pharmacology
#9,565
of 18,732 outputs
Outputs of similar age
#273,997
of 371,842 outputs
Outputs of similar age from Frontiers in Pharmacology
#34
of 60 outputs
Altmetric has tracked 24,677,985 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 18,732 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,842 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.