Title |
Cardiac cAMP: production, hydrolysis, modulation and detection
|
---|---|
Published in |
Frontiers in Pharmacology, October 2015
|
DOI | 10.3389/fphar.2015.00203 |
Pubmed ID | |
Authors |
Cédric Boularan, Céline Gales |
Abstract |
Cyclic adenosine 3',5'-monophosphate (cAMP) modulates a broad range of biological processes including the regulation of cardiac myocyte contractile function where it constitutes the main second messenger for β-adrenergic receptors' signaling to fulfill positive chronotropic, inotropic and lusitropic effects. A growing number of studies pinpoint the role of spatial organization of the cAMP signaling as an essential mechanism to regulate cAMP outcomes in cardiac physiology. Here, we will briefly discuss the complexity of cAMP synthesis and degradation in the cardiac context, describe the way to detect it and review the main pharmacological arsenal to modulate its availability. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 109 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 18% |
Student > Bachelor | 20 | 18% |
Student > Master | 15 | 14% |
Researcher | 10 | 9% |
Student > Doctoral Student | 8 | 7% |
Other | 12 | 11% |
Unknown | 24 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 30 | 28% |
Agricultural and Biological Sciences | 17 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 11% |
Medicine and Dentistry | 12 | 11% |
Engineering | 4 | 4% |
Other | 9 | 8% |
Unknown | 25 | 23% |