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Antinociceptive and neuropharmacological activities of methanol extract of Phoenix sylvestris fruit pulp

Overview of attention for article published in Frontiers in Pharmacology, October 2015
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Title
Antinociceptive and neuropharmacological activities of methanol extract of Phoenix sylvestris fruit pulp
Published in
Frontiers in Pharmacology, October 2015
DOI 10.3389/fphar.2015.00212
Pubmed ID
Authors

Shafiullah Shajib, Saleha Akter, Tajnin Ahmed, Mohammad Zafar Imam

Abstract

Fruits of Phoenix sylvestris Roxb. (Arecaceae) are used to treat back pain, toothache, headache, arthritis, nervous debility and as sedative. The aim of this study was to evaluate the antinociceptive and neuropharmacological activities of methanol extract of P. sylvestris fruit pulp (MEPS). The antinociceptive activity of MEPS was evaluated by heat-induced (hot plate, tail immersion test) and chemical-induced pain models (acetic acid-induced writhing, formalin-induced nociception, glutamate-induced nociception and paw edema test). The effect of MEPS on central nervous system (CNS) was studied using hole cross test, open field test, sodium thiopental-induced sleeping time and elevated plus maze test. MEPS showed strong, significant and dose-dependent antinociceptive activity in all heat-induced and chemical-induced pain models at all experimental doses. Involvement of opioid receptor mediated analgesia was evident from the reversal of analgesic effect by naloxone. MEPS also showed reduced locomotor activity in both hole cross and open field tests. The increase in sleeping time in sodium thiopental-induced sleeping test and anxiolytic activity in elevated plus maze test were also significant. So, it is evident that MEPS possesses strong central and peripheral antinociceptive activity as well as CNS depressant, sedative and anxiolytic activity. The results justify the ethnomedicinal use of P. sylvestris fruit in different painful conditions and CNS disorders.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 21%
Student > Ph. D. Student 5 12%
Researcher 4 9%
Student > Bachelor 3 7%
Professor > Associate Professor 3 7%
Other 5 12%
Unknown 14 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 14%
Agricultural and Biological Sciences 6 14%
Pharmacology, Toxicology and Pharmaceutical Science 5 12%
Medicine and Dentistry 5 12%
Nursing and Health Professions 3 7%
Other 3 7%
Unknown 15 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2015.
All research outputs
#18,428,159
of 22,829,683 outputs
Outputs from Frontiers in Pharmacology
#8,234
of 16,070 outputs
Outputs of similar age
#198,034
of 275,403 outputs
Outputs of similar age from Frontiers in Pharmacology
#60
of 103 outputs
Altmetric has tracked 22,829,683 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,070 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
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We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.