Title |
Antioxidant properties of HDL
|
---|---|
Published in |
Frontiers in Pharmacology, October 2015
|
DOI | 10.3389/fphar.2015.00222 |
Pubmed ID | |
Authors |
Handrean Soran, Jonathan D. Schofield, Paul N. Durrington |
Abstract |
High-density lipoprotein (HDL) provides a pathway for the passage of lipid peroxides and lysophospholipids to the liver via hepatic scavenger receptors. Perhaps more importantly, HDL actually metabolizes lipid hydroperoxides preventing their accumulation on low-density lipoprotein (LDL), thus impeding its atherogenic structural modification. A number of candidates have been suggested to be responsible for HDL's antioxidant function, with paraoxonase-1 (PON1) perhaps the most prominent. Here we review the evidence for HDL anti-oxidative function and the potential contributions of apolipoproteins, lipid transfer proteins, paraoxonases and other enzymes associated with HDL. |
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Unknown | 2 | 67% |
Demographic breakdown
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Members of the public | 3 | 100% |
Mendeley readers
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Demographic breakdown
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Student > Master | 23 | 14% |
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