Title |
A Rare Class of New Dimeric Naphthoquinones from Diospyros lotus have Multidrug Reversal and Antiproliferative Effects
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Published in |
Frontiers in Pharmacology, December 2015
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DOI | 10.3389/fphar.2015.00293 |
Pubmed ID | |
Authors |
Abdur Rauf, Ghias Uddin, Bina S. Siddiqui, Joseph Molnár, Ákos Csonka, Bashir Ahmad, Diana Szabó, Umar Farooq, Ajmal Khan |
Abstract |
Three new dimeric naphthoquinones, 5,4'-dihydroxy-1'-methoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,5',8'-tetraone (1), 5',8'-dihydroxy-5-methoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (2) and 8,5',8'-trihydroxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (3), were isolated from the roots of Diospyros lotus. Their structures were elucidated by spectroscopic techniques, including 1D and 2D NMR, such as HSQC, HMBS, NOESY, and J-resolved. Compounds 1-3 were evaluated for their effects on the reversion of multidrug resistance (MDR) mediated by P-glycoprotein through use of the rhodamine-123 exclusion screening test on human ABCB1 gene transfected L5178Y mouse T-cell lymphoma. Compounds 1-3 were also assessed for their antiproliferative and cytotoxic effects on L5178 and L5178Y mouse T-cell lymphoma lines. Both 1 and 2 exhibited promising antiproliferative and MDR-reversing effects in a dose-dependent manner. The effects of the tested compounds on the activity of doxorubicin were observed to vary from slight antagonism to antagonism. |
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Switzerland | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 18% |
Professor > Associate Professor | 3 | 18% |
Researcher | 3 | 18% |
Professor | 1 | 6% |
Student > Bachelor | 1 | 6% |
Other | 0 | 0% |
Unknown | 6 | 35% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 2 | 12% |
Engineering | 2 | 12% |
Sports and Recreations | 1 | 6% |
Chemistry | 1 | 6% |
Other | 1 | 6% |
Unknown | 8 | 47% |