Title |
Impacts of Ionizing Radiation on the Different Compartments of the Tumor Microenvironment
|
---|---|
Published in |
Frontiers in Pharmacology, March 2016
|
DOI | 10.3389/fphar.2016.00078 |
Pubmed ID | |
Authors |
Natacha Leroi, François Lallemand, Philippe Coucke, Agnès Noel, Philippe Martinive |
Abstract |
Radiotherapy (RT) is one of the most important modalities for cancer treatment. For many years, the impact of RT on cancer cells has been extensively studied. Recently, the tumor microenvironment (TME) emerged as one of the key factors in therapy resistance. RT is known to influence and modify diverse components of the TME. Hence, we intent to review data from the literature on the impact of low and high single dose, as well as fractionated RT on host cells (endothelial cells, fibroblasts, immune and inflammatory cells) and the extracellular matrix. Optimizing the schedule of RT (i.e., dose per fraction) and other treatment modalities is a current challenge. A better understanding of the cascade of events and TME remodeling following RT would be helpful to design optimal treatment combination. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 94 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 24% |
Student > Master | 19 | 20% |
Researcher | 10 | 11% |
Student > Doctoral Student | 7 | 7% |
Student > Bachelor | 7 | 7% |
Other | 13 | 14% |
Unknown | 16 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 18 | 19% |
Agricultural and Biological Sciences | 16 | 17% |
Medicine and Dentistry | 15 | 16% |
Immunology and Microbiology | 8 | 8% |
Engineering | 5 | 5% |
Other | 9 | 9% |
Unknown | 24 | 25% |