You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Drug Delivery Using Nanoparticles for Cancer Stem-Like Cell Targeting
|
|---|---|
| Published in |
Frontiers in Pharmacology, April 2016
|
| DOI | 10.3389/fphar.2016.00084 |
| Pubmed ID | |
| Authors |
Bing Lu, Xiaojia Huang, Jingxin Mo, Wei Zhao |
| Abstract |
The theory of cancer stem-like cell (or cancer stem cell, CSC) has been established to explain how tumor heterogeneity arises and contributes to tumor progression in diverse cancer types. CSCs are believed to drive tumor growth and elicit resistance to conventional therapeutics. Therefore, CSCs are becoming novel target in both medical researches and clinical studies. Emerging evidences showed that nanoparticles effectively inhibit many types of CSCs by targeting various specific markers (aldehyde dehydrogenases, CD44, CD90, and CD133) and signaling pathways (Notch, Hedgehog, and TGF-β), which are critically involved in CSC function and maintenance. In this review, we briefly summarize the current status of CSC research and review a number of state-of-the-art nanomedicine approaches targeting CSC. In addition, we discuss emerging therapeutic strategies using epigenetic drugs to eliminate CSCs and inhibit cancer cell reprogramming. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 11% |
| Australia | 1 | 11% |
| France | 1 | 11% |
| Switzerland | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Scientists | 2 | 22% |
Mendeley readers
The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 143 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 24% |
| Student > Postgraduate | 26 | 18% |
| Student > Master | 22 | 15% |
| Student > Bachelor | 20 | 14% |
| Researcher | 14 | 10% |
| Other | 11 | 8% |
| Unknown | 16 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 44 | 31% |
| Agricultural and Biological Sciences | 23 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 12% |
| Medicine and Dentistry | 12 | 8% |
| Chemistry | 9 | 6% |
| Other | 16 | 11% |
| Unknown | 23 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2016.
All research outputs
#6,385,575
of 22,860,626 outputs
Outputs from Frontiers in Pharmacology
#2,604
of 16,133 outputs
Outputs of similar age
#91,351
of 300,876 outputs
Outputs of similar age from Frontiers in Pharmacology
#22
of 95 outputs
Altmetric has tracked 22,860,626 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 16,133 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,876 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.