Title |
The Pharmacological Potential of Non-ribosomal Peptides from Marine Sponge and Tunicates
|
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Published in |
Frontiers in Pharmacology, October 2016
|
DOI | 10.3389/fphar.2016.00333 |
Pubmed ID | |
Authors |
Shivankar Agrawal, Alok Adholeya, Sunil K. Deshmukh |
Abstract |
Marine biodiversity is recognized by a wide and unique array of fascinating structures. The complex associations of marine microorganisms, especially with sponges, bryozoans, and tunicates, make it extremely difficult to define the biosynthetic source of marine natural products or to deduce their ecological significance. Marine sponges and tunicates are important source of novel compounds for drug discovery and development. Majority of these compounds are nitrogen containing and belong to non-ribosomal peptide (NRPs) or mixed polyketide-NRP natural products. Several of these peptides are currently under trial for developing new drugs against various disease areas, including inflammatory, cancer, neurodegenerative disorders, and infectious disease. This review features pharmacologically active NRPs from marine sponge and tunicates based on their biological activities. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 76 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 12 | 16% |
Student > Ph. D. Student | 11 | 14% |
Student > Master | 11 | 14% |
Student > Doctoral Student | 6 | 8% |
Researcher | 6 | 8% |
Other | 13 | 17% |
Unknown | 17 | 22% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 15 | 20% |
Agricultural and Biological Sciences | 14 | 18% |
Chemistry | 13 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 11% |
Environmental Science | 3 | 4% |
Other | 6 | 8% |
Unknown | 17 | 22% |